Article
Production of the cryptic EefABC efflux pump in Enterobacter aerogenes chloramphenicol-resistant mutants.
The Journal of antimicrobial chemotherapy - 1 Jun 2006
Masi Muriel, Pagès Jean-Marie, Pradel Elizabeth
Abstract excerpt
OBJECTIVES: AcrAB-TolC is the major tripartite multidrug efflux pump in Enterobacter aerogenes while EefABC is a cryptic efflux system. This study was conducted to identify and characterize E. aerogenes mutants producing the EefABC efflux pump. METHODS: Four spontaneous chloramphenicol-resistant (CMR) mutants were isolated. The expression level of the eefABC promoter and the production of the EefA and B proteins...
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