Article
Tumor necrosis factor involvement in 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated endotoxin hypersensitivity in C57BL/6J mice congenic at the Ah locus.
Toxicology and applied pharmacology - 1 Dec 1991
Clark G C, Taylor M J, Tritscher A M, Lucier G W
Abstract excerpt
An experimental model of endotoxin-induced release of tumor necrosis factor-alpha (TNF) into the serum of C57BL/6J mice congenic at the Ah locus was used to investigate the effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) on TNF production. TCDD exposure of Ah-responsive mice (Ahbb) resulted...
Topics
- Alleles
- Animals
- Dose-Response Relationship, Drug
- Drug Hypersensitivity
- Endotoxins
- Female
- Male
- Mice
- Mice, Inbred C57BL
- Polychlorinated Dibenzodioxins
- Receptors, Aryl Hydrocarbon
- Receptors, Drug
- Tumor Necrosis Factor-alpha