Article
High rate of proV47A selection in HIV-2 patients failing lopinavir-based HAART.
AIDS (London, England) - 2 Jan 2006
Rodés Berta, Toro Carlos, Sheldon Julie A, Jiménez Victoria, Mansinho Kamal, Soriano Vincent
Abstract excerpt
We describe the emergence of the proV47A mutation in three out of five HIV-2-infected individuals failing lopinavir/ritonavir-based HAART. The appearance of such mutated variants resulted in high levels of phenotypic resistance to lopinavir, cross-resistance to indinavir, amprenavir, and hypersusceptibility to saquinavir. A search in HIV-2 databases revealed that proV47A is present in 8.6% of protease inhibitor...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.