Article
Dual endothelin receptor antagonists contrast the effects induced by endothelin-1 on cultured human microvascular endothelial cells.
Clinical and experimental rheumatology - 1 Jan 2000
Soldano Stefano, Paolino Sabrina, Pizzorni Carmen, Trombetta Amelia Chiara, Montagna Paola, Brizzolara Renata, Corallo Claudio, Giordano Nicola, Sulli Alberto, Cutolo Maurizio
Abstract excerpt
OBJECTIVES: To evaluate the ability of dual endothelin (ET) receptor antagonists (ETA/ETB -ETA/BRAs) to contrast the ET-1-induced effects on cultured human microvascular endothelial cells (HMVECs). METHODS: Some cultured HMVECs were untreated, or treated with ET-1 (100nM) or transforming growth factor β1 (TGFβ1, 10ng/mL) alone for 6 days, in order to induce the endothelial-to-mesenchymal transition (EndoMT)....
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