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Article

In vivo role of different domains and of phosphorylation in the transcription factor Nkx2-1.

BMC developmental biology - 23 Feb 2011

Silberschmidt Daniel, Rodriguez-Mallon Alina, Mithboakar Prathiba, Calì Gaetano, Amendola Elena, Sanges Remo, Zannini Mariastella, Scarfò Marzia, De Luca Pasquale, Nitsch Lucio, Di Lauro Roberto, De Felice Mario

Abstract excerpt

BACKGROUND: The transcription factor Nkx2-1 (also known as TTF-1, Titf1 or T/EBP) contains two apparently redundant activation domains and is post-translationally modified by phosphorylation. We have generated mouse mutant strains to assess the roles of the two activation domains and of phosphorylation in mouse development and differentiation. RESULTS: Mouse strains expressing variants of the transcription factor...

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Identifiers

PMID: 21345181
DOI: 10.1186/1471-213X-11-9
PMCID: PMC3055846

Genes

EBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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