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Article

Analysing the ability to retain sidechain hydrogen-bonds in mutant proteins.

Bioinformatics (Oxford, England) - 15 Jun 2006

Cuff Alison L, Janes Robert W, Martin Andrew C R

Abstract excerpt

MOTIVATION: Hydrogen bonds are one of the most important inter-atomic interactions in biology. Previous experimental, theoretical and bioinformatics analyses have shown that the hydrogen bonding potential of amino acids is generally satisfied and that buried unsatisfied hydrogen-bond-capable residues are destabilizing. When studying mutant proteins, or introducing mutations to residues involved in hydrogen...

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PMID: 16601005
DOI: 10.1093/bioinformatics/btl120

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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