Article

OPUS-Mut: studying the effect of protein mutation through side-chain modeling

2022-05-11

Abstract excerpt

Predicting the effect of protein mutation is crucial in many applications such as protein design, protein evolution, and genetic disease analysis. Structurally, the mutation is basically the replacement of the side chain of a particular residue. Therefore, accurate side-chain modeling is useful in studying the effect of mutation. Here, we propose a computational method, namely OPUS-Mut, which significantly outperf...

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Literature Corpus work: bde6c122-da81-5d02-b862-3b86577d8d7e
DOI: 10.1101/2022.05.10.491420

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