Article
Association of bradykinin receptor 2 (BDKRB2) variants with physical performance and muscle mass: Findings from the LACE sarcopenia trial.
PloS one - 1 Jan 2024
Shrestha Alvin, Bashir Tufail, Achison Marcus, Adamson Simon, Akpan Asangaedem, Aspray Terry, Avenell Alison, Band Margaret M, Burton Louise A, Cvoro Vera, Donnan Peter T, Duncan Gordon W, George Jacob, Gordon Adam L, Gregson Celia L, Hapca Adrian, Hume Cheryl, Jackson Thomas A, Kerr Simon, Kilgour Alixe, Masud Tahir, McKenzie Andrew, McKenzie Emma, Patel Harnish, Pilvinyte Kristina, Roberts Helen C, Sayer Avan A, Rossios Christos, Smith Karen T, Soiza Roy L, Steves Claire J, Struthers Allan D, Tiwari Divya, Whitney Julie, Witham Miles D, Kemp Paul R
Abstract excerpt
INTRODUCTION: Understanding genetic contributors to sarcopenia (age-related loss of muscle strength and mass) is key to finding effective therapies. Variants of the bradykinin receptor 2 (BDKRB2) have been linked to athletic and muscle performance. The rs1799722-9 and rs5810761 T alleles have been shown to be overrepresented in endurance athletes, possibly due to increased transcriptional rates of the receptor....
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