A herpes simplex type 1 ICPO deletion mutant demonstrates diminished pathogenicity during acute ocular infection in different host animals.

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Article

A herpes simplex type 1 ICPO deletion mutant demonstrates diminished pathogenicity during acute ocular infection in different host animals.

Investigative ophthalmology & visual science - 1 Apr 1990

Gordon Y J, Romanowski E, Balouris C, Araullo-Cruz T

Abstract excerpt

We compared a previously characterized herpes simplex type 1 alpha 0 deletion mutant, dlx3.1, which produced no functional ICP0, with its wild-type parental strain, KOS, during acute ocular infection of different host animals. Acute pathogenicity of the viral strains in NZ rabbits, Balb/c and A/J...

Topics

Acute Disease
Animals
Chromosome Deletion
Eye
Female
Keratitis, Dendritic
Male
Mice
Mice, Inbred BALB C
Mice, Inbred Strains
Mutation
Rabbits
Simplexvirus
Survival
Trigeminal Ganglion

Source

Open in PubMed

Identifiers

PMID: 2159449

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2159449-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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