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Article

Functional nsSNPs from carcinogenesis-related genes expressed in breast tissue: potential breast cancer risk alleles and their distribution across human populations.

Human genomics - 1 Mar 2006

Savas Sevtap, Schmidt Steffen, Jarjanazi Hamdi, Ozcelik Hilmi

Abstract excerpt

Although highly penetrant alleles of BRCA1 and BRCA2 have been shown to predispose to breast cancer, the majority of breast cancer cases are assumed to result from the presence of low-moderate penetrant alleles and environmental carcinogens. Non-synonymous single nucleotide polymorphisms (nsSNPs) are hypothesised to contribute to disease susceptibility and approximately 30 per cent of them are predicted to have a...

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Identifiers

PMID: 16595073
DOI: 10.1186/1479-7364-2-5-287
PMCID: PMC3500178

Genes

BRCA1
BRCA2

Provenance

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