Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Frequency and treatment-related predictors of thymidine-analogue mutation patterns in HIV-1 isolates after unsuccessful antiretroviral therapy.

The Journal of infectious diseases - 1 May 2006

De Luca Andrea, Di Giambenedetto Simona, Romano Laura, Gonnelli Angela, Corsi Paola, Baldari Marco, Di Pietro Massimo, Menzo Stefano, Francisci Daniela, Almi Paolo, Zazzi Maurizio

Abstract excerpt

We investigated, in patients tested between 1991 and 2004, the patterns of mutually exclusive human immunodeficiency virus-1 thymidine-analogue mutations (TAMs) in 4039 reverse-transcriptase sequences with > or = 1 TAM. TAM pattern 1, which included M41L and L210W and excluded K70R and is coupled with more-extensive cross-resistance to drugs, became the most frequent pattern after 1996. In 1465 genotypes from 684...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-HIV Agents
Share to Antiretroviral Therapy, Highly Active

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Viral

Share to Drug Resistance, Multiple, Viral

Share to HIV Infections

Share to HIV Reverse Transcriptase

Share to Reverse Transcriptase Inhibitors

Share to Thymidine

Source

Identifiers

PMID: 16586357
DOI: 10.1086/502976

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Frequency and treatment-related predictors of thymidine-analogue mutation patterns in HIV-1 isolates after unsuccessful antiretroviral therapy.PMID 16586357Read ↗

Resistance-associated mutations after initial antiretroviral treatment failure in a large cohort of patients infected with HIV-1 subtype CRF01_AE.Semantic proximity Read ↗

Diversity of thymidine analogue resistance genotypes among newly diagnosed HIV-1-infected persons.Semantic proximity Read ↗

Thymidine analogue reverse transcriptase inhibitors resistance mutations profiles and association to other nucleoside reverse transcriptase inhibitors resistance mutations observed in the context of virological failure.Semantic proximity Read ↗

Thymidine analogue mutation profiles: factors associated with acquiring specific profiles and their impact on the virological response to therapy.Semantic proximity Read ↗

Thymidine analogue mutations in antiretroviral-naive HIV-1 patients on triple therapy including either zidovudine or stavudine.Semantic proximity Read ↗

Changing rates and patterns of drug resistance mutations in antiretroviral-experienced HIV-infected patients.Semantic proximity Read ↗

Evolving patterns of HIV-1 resistance to antiretroviral agents in newly infected individuals.Semantic proximity Read ↗

Involvement of Novel Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutations in the Regulation of Resistance to Nucleoside InhibitorsSemantic proximity Read ↗

Occult HIV-1 drug resistance to thymidine analogues following failure of first-line tenofovir combined with a cytosine analogue and nevirapine or efavirenz in sub Saharan Africa: a retrospective multi-centre cohort study.Semantic proximity Read ↗

Trend of drug-resistant HIV type 1 emergence among therapy-naive patients in Nagoya, Japan: an 8-year surveillance from 1999 to 2006.Semantic proximity Read ↗

Frequency and diversity of human immunodeficiency virus type 1 mutations associated with antiretroviral resistance among patients from Southern Brazil failing highly active antiretroviral therapy (HAART).Semantic proximity Read ↗

Changing patterns in HIV reverse transcriptase resistance mutations after availability of tenofovir.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.