Article
Trend of drug-resistant HIV type 1 emergence among therapy-naive patients in Nagoya, Japan: an 8-year surveillance from 1999 to 2006.
AIDS research and human retroviruses - 1 Jan 2008
Ibe Shiro, Hattori Junko, Fujisaki Seiichiro, Shigemi Urara, Fujisaki Saeko, Shimizu Kayoko, Nakamura Kazuyo, Kazumi Takejiro, Yokomaku Yoshiyuki, Mamiya Naoto, Hamaguchi Motohiro, Kaneda Tsuguhiro
Abstract excerpt
We studied the emergence of drug-resistant human immunodeficiency virus type 1 (HIV-1) with major amino acid mutations in 402 therapy-naive patients at Nagoya Medical Center, Japan, between 1999 and 2006. The mean prevalence of drug-resistant HIV-1 was 6.7% (range, 2.3-10.0%; n = 27). HIV-1 variants with protease inhibitor (PI)-resistant mutations alone were most frequently found (3.5%, n = 14), followed by those...
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