Article
Changing patterns in HIV reverse transcriptase resistance mutations after availability of tenofovir.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Jun 2008
de Mendoza Carmen, Jiménez-Nacher Inmaculada, Garrido Carolina, Barreiro Pablo, Poveda Eva, Corral Angélica, Zahonero Natalia, González-Lahoz Juan, Soriano Vincent
Abstract excerpt
Assessment of 1177 human immunodeficiency virus (HIV) resistance genotypes at an HIV/AIDS clinic showed a decrease in the incidence of the K65R mutation, from 15.2% of isolates during the period 2002-2004 to 2.7% of isolates during the period 2005-2006 (P < .001), despite elevated and stable rates of tenofovir use. A reduction in the rate of coadministration of didanosine (from 41.6% of patients in 2004 to 0.8%...
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