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Article

A single nucleotide polymorphism chip-based method for combined genetic and epigenetic profiling: validation in decitabine therapy and tumor/normal comparisons.

Cancer research - 1 Apr 2006

Yuan Eric, Haghighi Fatemeh, White Susan, Costa Ramiro, McMinn Julie, Chun Kathy, Minden Mark, Tycko Benjamin

Abstract excerpt

Progress on several unresolved issues in cancer epigenetics will benefit from rapid and standardized methods for profiling DNA methylation genome-wide. In the area of epigenetic therapy, the demethylating drug decitabine (5-aza-2'-deoxycytidine) is increasingly used to treat acute myelogenous leukemia and myelodysplastic syndrome, but the mechanisms of its anticancer activity have remained unclear. Given the...

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PMID: 16585166
DOI: 10.1158/0008-5472.CAN-05-3739

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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