Article
Interleukin-18 gene promoter and serum level in women with ovarian cancer.
Molecular biology reports - 1 Nov 2009
Samsami Dehaghani Alamtaj, Shahriary Khatere, Kashef Mohammad Amin, Naeimi Sirous, Fattahi Mohammad Javad, Mojtahedi Zahra, Ghaderi Abbas
Abstract excerpt
IL-18, initially defined as a potent inducer of IFN- gamma production, is a systemic, multifunctional cytokine with both pro-cancerous and anti-cancer activities. The contribution of the IL-18 promoter polymorphisms at positions -607 (C/A) and -137 (G/C) to cancer development has been reported. We sought to examine IL-18 serum level and its polymorphisms in Iranian women with ovarian cancer. Single nucleotide...
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