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Article

Interleukin-18 promoter polymorphisms and risk of idiopathic recurrent pregnancy loss in a Tunisian population.

Journal of reproductive immunology - 1 Mar 2012

Messaoudi Safia, Dandana Maryam, Magdoud Kalthoum, Meddeb Sawssen, Ben Slama Neila, Hizem Sondes, Mahjoub Touhami

Abstract excerpt

IL-18 is a pro-inflammatory cytokine that regulates the differentiation and effector functions of CD4+ (Th1) and CD8+ (CTL) T cells, which are implicated in the pathogenesis of recurrent pregnancy loss (RPL). We investigated the association of the IL-18 gene promoter single nucleotide polymorphisms (SNPs) -656C/A (rs1946519), -137G/C (rs187238), -119A/C (rs360718), and -105G/A (rs360717), by TaqMan assays in...

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PMID: 22386125
DOI: 10.1016/j.jri.2011.12.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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