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Article

Association between the DRD2 A1 allele and response to methadone and buprenorphine maintenance treatments.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jun 2006

Barratt Daniel T, Coller Janet K, Somogyi Andrew A

Abstract excerpt

The TaqI A polymorphism (A(1)) of the dopamine D(2) receptor gene (DRD2), although not a specific predictor of opioid dependence, has been strongly associated with high levels of prior heroin use and poor treatment outcomes among methadone maintenance patients. The aims of this study were to confirm these findings via a retrospective analysis of A(1) allele frequency in methadone (n = 46) and buprenorphine (n =...

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Share to Analgesics, Opioid
Share to Deoxyribonucleases, Type II Site-Specific

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heroin Dependence

Share to Methadone

Share to Receptors, Dopamine D2

Share to Substance Withdrawal Syndrome

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Source

Identifiers

PMID: 16583408
DOI: 10.1002/ajmg.b.30319

Genes

DRD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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