A polymorphism of the methionine synthase reductase gene increases chromosomal damage in peripheral lymphocytes in smokers.

doi:10.1016/j.mrfmmm.2006.02.004

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Article

A polymorphism of the methionine synthase reductase gene increases chromosomal damage in peripheral lymphocytes in smokers.

Mutation research - 25 Jul 2006

Ishikawa Hitoshi, Ishikawa Takashi, Miyatsu Yu, Kurihara Kazuo, Fukao Akira, Yokoyama Kazuhito

Abstract excerpt

The cytogenetic effects of cigarette smoke has been evaluated as one of many potential confounders in a large number of biomonitoring studies of occupationally or environmentally exposed populations and control subjects. Despite the well-known presence of carcinogens in the cigarette smoke, the results in the scientific literature linking smoking habits to micronuclei (MN) frequency, one of the cytogenetic...

Topics

5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Adult
DNA Damage
Ferredoxin-NADP Reductase
Genotype
Humans
Lymphocytes
Male
Methylenetetrahydrofolate Reductase (NADPH2)
Micronucleus Tests
Middle Aged
Polymorphism, Genetic
Smoking
Thymidylate Synthase

Source

Open in PubMed

Identifiers

PMID: 16580699
DOI: 10.1016/j.mrfmmm.2006.02.004

Genes

MTRR
MTHFR
MTR
TYMS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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