Article
MAU-8 is a Phosducin-like Protein required for G protein signaling in C. elegans.
Developmental biology - 1 Jun 2006
Lacoste Caroline, Barthaux Véronique, Iborra Cécile, Seagar Michael, Erard-Garcia Madeleine
Abstract excerpt
The mau-8(qm57) mutation inhibits the function of GPB-2, a heterotrimeric G protein beta subunit, and profoundly affects behavior through the Galphaq/Galphao signaling network in C. elegans. mau-8 encodes a nematode Phosducin-like Protein (PhLP), and the qm57 mutation leads to the loss of a predicted phosphorylation site in the C-terminal domain of PhLP that binds the Gbetagamma surface implicated in membrane...
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