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Article

Complement regulator CD46: genetic variants and disease associations.

Human genomics - 10 Jun 2015

Liszewski M Kathryn, Atkinson John P

Abstract excerpt

Membrane cofactor protein (MCP; CD46) is an ubiquitously expressed complement regulatory protein that protects host cells from injury by complement. This type-I membrane glycoprotein serves as a cofactor for the serine protease factor I to mediate inactivation of C3b and C4b deposited on host cells. More than 60 disease-associated mutations in MCP have now been identified. The majority of the mutations are linked...

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Identifiers

PMID: 26054645
DOI: 10.1186/s40246-015-0029-z
PMCID: PMC4469999

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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