Article
Detection of divergent genes in microbial aCGH experiments.
BMC bioinformatics - 30 Mar 2006
Snipen Lars, Repsilber Dirk, Nyquist Ludvig, Ziegler Andreas, Aakra Agot, Aastveit Are
Abstract excerpt
BACKGROUND: Array-based comparative genome hybridization (aCGH) is a tool for rapid comparison of genomes from different bacterial strains. The purpose of such analysis is to detect highly divergent or absent genes in a sample strain compared to an index strain. Development of methods for analyzing aCGH data has primarily focused on copy number abberations in cancer research. In microbial aCGH analyses, genes are...
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