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Article

Epigenetic alteration of the dopamine transporter gene in alcohol‐dependent patients is associated with age

16 Apr 2012

Abstract excerpt

Chronic alcohol abuse and dependence are associated with dysfunctional dopaminergic neurotransmission in mesocorticolimbic circuits. Genetic and environmental factors have been shown to modulate susceptibility to alcohol dependence, and both may act through epigenetic mechanisms that can modulate gene expression, e.g. DNA methylation at CpG sites. Recent studies have suggested that DNA methylation patterns may...

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PMID: 22506971
DOI: 10.1111/j.1369-1600.2012.00459.x

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