Article
Aflatoxin B1 and polycyclic aromatic hydrocarbon adducts, p53 mutations and p16 methylation in liver tissue and plasma of hepatocellular carcinoma patients.
International journal of cancer - 1 Sept 2006
Zhang Yu-Jing, Rossner Pavel, Chen Yu, Agrawal Meenakshi, Wang Qiao, Wang Lillian, Ahsan Habibul, Yu Ming-Whei, Lee Po-Huang, Santella Regina M
Abstract excerpt
Elevated aflatoxin B(1)-albumin adducts (AFB(1)-Alb) have been associated with an increased risk for HCC development. However, there are no studies in humans, correlating albumin adducts in blood with liver DNA adducts. Forty frozen tumor tissues and 39 paired plasma samples from HCC patients were collected in Taiwan, to determine the relationship between albumin adducts in blood and DNA adducts in liver tissue...
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