Article
The influence of various genotypes on the metabolic activity of NAT2 in a Chinese population.
European journal of clinical pharmacology - 1 May 2006
Chen Bing, Zhang Wei-Xia, Cai Wei-Min
Abstract excerpt
AIM: To determine the phenotype and genotype of NAT2 in a Chinese population and study the influence of various NAT2 genotypes on the NAT2 activity. METHODS: A reverse dot blot method was used to detect the genotype of NAT2 in 120 healthy Chinese subjects. All subjects were given a single dose of 500 mg sulphadimidine (SM(2)). The plasma concentration of SM(2) and acetyl-SM(2) (AcSM(2)) 6 h after administration...
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