Article
Increased resistance to multiple drugs by introduction of the Enterobacter cloacae romA gene into OmpF porin-deficient mutants of Escherichia coli K-12.
Antimicrobial agents and chemotherapy - 1 Oct 1991
Komatsu T, Ohta M, Kido N, Arakawa Y, Ito H, Kato N
Abstract excerpt
Introduction of the romA gene cloned from Enterobacter cloacae into Escherichia coli K-12 resulted in almost complete inhibition of OmpF expression and a concomitant increase in resistance to quinolones, beta-lactams, chloramphenicol, and tetracyclines. In addition, the romA gene reduced the susceptibility to these multiple drugs even in the OmpF porin-deficient mutants of E. coli K-12. Results indicate the...
Topics
- Anti-Bacterial Agents
- Bacterial Outer Membrane Proteins
- Drug Resistance, Microbial
- Electrophoresis, Polyacrylamide Gel
- Enterobacter cloacae
- Escherichia coli
- Genes, Bacterial
- Microbial Sensitivity Tests
- Mutation
- Plasmids