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Article

Why are carbapenems active against Enterobacter cloacae resistant to third generation cephalosporins?

Scandinavian journal of infectious diseases. Supplementum - 1 Jan 1991

Pechère J C

Abstract excerpt

The broad antibacterial activity of carbapenems includes Gram-negative rods resistant to third generation cephalosporins. To increase the understanding of this improved activity, the factors involved in the efficacy of imipenem and ceftriaxone against Enterobacter cloacae have been examined. Resistance to ceftriaxone is primarily the result of a selection of resistant clones ("derepressed mutants"), pre-existing...

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PMID: 1658922

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Why are carbapenems active against Enterobacter cloacae resistant to third generation cephalosporins?PMID 1658922Read ↗

The contribution of porins to enterobacterial drug resistance.Semantic proximity Read ↗

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Consecutive mutations leading to the emergence in vivo of imipenem resistance in a clinical strain of Enterobacter aerogenes.Semantic proximity Read ↗

Activity of cefepime and other beta-lactam antibiotics against permeability mutants of Escherichia coli and Klebsiella pneumoniae.Semantic proximity Read ↗

Prevalence of outer membrane porin alteration in beta-lactam-antibiotic-resistant Enterobacter aerogenes.Semantic proximity Read ↗

Extension of resistance to cefepime and cefpirome associated to a six amino acid deletion in the H-10 helix of the cephalosporinase of an<i>Enterobacter cloacae</i>clinical isolateSemantic proximity Read ↗

In vivo modification of porin activity conferring antibiotic resistance to Enterobacter aerogenes.Semantic proximity Read ↗

Hydrolytic rate at low drug concentration as a limiting factor in resistance to newer cephalosporins.Semantic proximity Read ↗

Effect of cefoxitin and clindamycin on selection of derepressed mutants in Enterobacter cloacae.Semantic proximity Read ↗

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