Article
Chemical modulation of receptor signaling inhibits regenerative angiogenesis in adult zebrafish.
Nature chemical biology - 1 May 2006
Bayliss Peter E, Bellavance Kimberly L, Whitehead Geoffrey G, Abrams Joshua M, Aegerter Sandrine, Robbins Heather S, Cowan Douglas B, Keating Mark T, O'Reilly Terence, Wood Jeanette M, Roberts Thomas M, Chan Joanne
Abstract excerpt
We examined the role of angiogenesis and the need for receptor signaling using chemical inhibition of the vascular endothelial growth factor receptor in the adult zebrafish tail fin. Using a small-molecule inhibitor, we were able to exert precise control over blood vessel regeneration. An angiogenic limit to tissue regeneration was determined, as avascular tissue containing skin, pigment, neuronal axons and bone...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.