Article
RNAi-mediated gene silencing in non-human primates.
Nature - 4 May 2006
Zimmermann Tracy S, Lee Amy C H, Akinc Akin, Bramlage Birgit, Bumcrot David, Fedoruk Matthew N, Harborth Jens, Heyes James A, Jeffs Lloyd B, John Matthias, Judge Adam D, Lam Kieu, McClintock Kevin, Nechev Lubomir V, Palmer Lorne R, Racie Timothy, Röhl Ingo, Seiffert Stephan, Shanmugam Sumi, Sood Vandana, Soutschek Jürgen, Toudjarska Ivanka, Wheat Amanda J, Yaworski Ed, Zedalis William, Koteliansky Victor, Manoharan Muthiah, Vornlocher Hans-Peter, MacLachlan Ian
Abstract excerpt
The opportunity to harness the RNA interference (RNAi) pathway to silence disease-causing genes holds great promise for the development of therapeutics directed against targets that are otherwise not addressable with current medicines. Although there are numerous examples of in vivo silencing of target genes after local delivery of small interfering RNAs (siRNAs), there remain only a few reports of RNAi-mediated...
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