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Article

ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors.

The Journal of clinical investigation - 1 Aug 2016

Gordts Philip L S M, Nock Ryan, Son Ni-Huiping, Ramms Bastian, Lew Irene, Gonzales Jon C, Thacker Bryan E, Basu Debapriya, Lee Richard G, Mullick Adam E, Graham Mark J, Goldberg Ira J, Crooke Rosanne M, Witztum Joseph L, Esko Jeffrey D

Abstract excerpt

Hypertriglyceridemia is an independent risk factor for cardiovascular disease, and plasma triglycerides (TGs) correlate strongly with plasma apolipoprotein C-III (ApoC-III) levels. Antisense oligonucleotides (ASOs) for ApoC-III reduce plasma TGs in primates and mice, but the underlying mechanism of action remains controversial. We determined that a murine-specific ApoC-III-targeting ASO reduces fasting TG levels...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 27400128
DOI: 10.1172/JCI86610
PMCID: PMC4966320

Genes

LRP1
LDLR
LPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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