Insight into the nature of the CRP-coronary event association using Mendelian randomization.

doi:10.1093/ije/dyl041

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Article

Insight into the nature of the CRP-coronary event association using Mendelian randomization.

International journal of epidemiology - 1 Aug 2006

Casas Juan P, Shah Tina, Cooper Jackie, Hawe Emma, McMahon Alex D, Gaffney Dairena, Packard Christopher J, O'Reilly Denis S, Juhan-Vague Irene, Yudkin John S, Tremoli Elena, Margaglione Maurizio, Di Minno Giovanni, Hamsten Anders, Kooistra Teake, Stephens Jeffrey W, Hurel Steven J, Livingstone Shona, Colhoun Helen M, Miller George J, Bautista Leonelo E, Meade Tom, Sattar Naveed, Humphries Steve E, Hingorani Aroon D

Abstract excerpt

BACKGROUND: It is unclear wheather the association between C-reactive protein (CRP) and incident coronary events is free from bias and confounding. Individuals homozygous for a +1444C>T polymorphism in the CRP gene have higher circulating concentrations of CRP. Since the distribution of this polymorphism occurs at random during gamete formation, its association with coronary events should not be biased or...

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PMID: 16565153
DOI: 10.1093/ije/dyl041

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