Article
The association of C-reactive protein and CRP genotype with coronary heart disease: findings from five studies with 4,610 cases amongst 18,637 participants.
PloS one - 20 Aug 2008
Lawlor Debbie A, Harbord Roger M, Timpson Nic J, Lowe Gordon D O, Rumley Ann, Gaunt Tom R, Baker Ian, Yarnell John W G, Kivimäki Mika, Kumari Meena, Norman Paul E, Jamrozik Konrad, Hankey Graeme J, Almeida Osvaldo P, Flicker Leon, Warrington Nicole, Marmot Michael G, Ben-Shlomo Yoav, Palmer Lyle J, Day Ian N M, Ebrahim Shah, Smith George Davey
Abstract excerpt
BACKGROUND: It is unclear whether C-reactive protein (CRP) is causally related to coronary heart disease (CHD). Genetic variants that are known to be associated with CRP levels can be used to provide causal inference of the effect of CRP on CHD. Our objective was to examine the association between CRP genetic variant +1444C>T (rs1130864) and CHD risk in the largest study to date of this association. METHODS AND...
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