Article
Hyaluronan release from Streptococcus pyogenes: export by an ABC transporter.
Glycobiology - 1 Oct 2004
Ouskova Galina, Spellerberg Barbara, Prehm Peter
Abstract excerpt
Capsular hyaluronan of Streptococcus pyogenes is synthesized at the protoplast membrane. It is widely assumed that hyaluronan is exported by the synthase itself and that no additional protein is required for transfer through plasma membranes. However, we produced an insertional mutation that reduced the mucoid phenotype, hyaluronan production, and capsule formation. Nucleotide sequence analysis of the insertion...
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