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Article

Eradication of p53-mutated head and neck squamous cell carcinoma xenografts using nonviral p53 gene therapy and photochemical internalization.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Jun 2006

Ndoye Alioune, Dolivet Gilles, Høgset Anders, Leroux Agnès, Fifre Alexandre, Erbacher Patrick, Berg Kristian, Behr Jean-Paul, Guillemin François, Merlin Jean-Louis

Abstract excerpt

Photochemical internalization (PCI) technology has been used for PEI-mediated p53 gene transfer in mice bearing head and neck squamous cell carcinoma (HNSCC) xenografts. Using luciferase as a reporter gene, PCI led to a 20-fold increase in transgene expression 48 h after transfection and sustained transgene expression for 7 days. Therefore, iterative p53 gene transfer was performed by means of a weekly single...

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PMID: 16564229
DOI: 10.1016/j.ymthe.2006.02.003

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MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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