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Combining Oncolytic Virotherapy with p53 Tumor Suppressor Gene Therapy

21 Mar 2017

Abstract excerpt

Oncolytic virus (OV) therapy utilizes replication-competent viruses to kill cancer cells, leaving non-malignant cells unharmed. With the first U.S. Food and Drug Administration-approved OV, dozens of clinical trials ongoing, and an abundance of translational research in the field, OV therapy is poised to be one of the leading treatments for cancer. A number of recombinant OVs expressing a transgene for p53 (TP53)...

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PMID: 28480326
DOI: 10.1016/j.omto.2017.03.002

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