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Article

Genetic analysis of the gyrase A-like domain of DNA topoisomerase II of Saccharomyces cerevisiae.

Genetics - 1 Aug 1991

Thomas W, Spell R M, Ming M E, Holm C

Abstract excerpt

We have undertaken a genetic analysis of heat-sensitive and cold-sensitive mutations in TOP2, the gene encoding yeast DNA topoisomerase II. Deletion mapping was used to localize 14 heat-sensitive and four cold-sensitive top2 mutations created by a method biased toward mutations in the 3' two-thirds of the gene. The mutations all appear to be located in the region of DNA topoisomerase II that shows homology to the...

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Identifiers

PMID: 1655564
DOI: 10.1093/genetics/128.4.703
PMCID: PMC1204545

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