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Article

Altered methylprednisolone pharmacodynamics in healthy subjects with histamine N-methyltransferase C314T genetic polymorphism.

Journal of clinical pharmacology - 1 Apr 2006

Hon Yuen Yi, Jusko William J, Spratlin Vicky E, Jann Michael W

Abstract excerpt

This study investigated the potential differences in methylprednisolone pharmacodynamics between healthy subjects with different histamine N-methyltransferase (HNMT) C314T genotypes. Six individuals with C/C genotype and 4 with C/T genotype were administered a single intravenous dose of methylprednisolone 0.6 mg/kg ideal body weight in a randomized 2-period manner. Methylprednisolone plasma concentrations were...

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Source

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Identifiers

PMID: 16554448
DOI: 10.1177/0091270006286434
PMCID: PMC4196422

Genes

HNMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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