Article
Histamine N-methyltransferase gene polymorphisms in Chinese and their relationship with enzyme activity in erythrocytes.
Pharmacogenetics - 1 Jul 2003
Chen Guo-Lin, Wang Haijian, Wang Wei, Xu Zhen-Hua, Zhou Gan, He Fuchu, Zhou Hong-Hao
Abstract excerpt
The aim of this study was to identify polymorphisms in the histamine N-methyltransferase (HNMT) gene in Chinese and to assess their relationship with HNMT activity. One hundred and ninety-two unrelated subjects were recruited. HNMT polymorphisms were screened by direct sequencing with purified polymerase chain reaction products comprising all six exons, plus splice junctions, as well as approximately 2 kb of the...
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