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Article

Different evolution of simian immunodeficiency virus in a natural host and a new host.

Virology - 20 Jul 1998

Courgnaud V, Saurin W, Villinger F, Sonigo P

Abstract excerpt

To address the mechanisms of host-virus adaptation and pathogenesis of lentiviral infections, we compared the evolution of the same isolate of simian immunodeficiency virus (SIVsmm9) in two different situations: nonpathogenic infection of its natural host, the sooty mangabey, and AIDS-inducing infection of a new host, the rhesus macaque. Samples were obtained at 6, 12, and 23 or 30 months postinfection from three...

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PMID: 9683570
DOI: 10.1006/viro.1998.9217

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