Article
Rapid detection of specific gene mutations associated with isoniazid or rifampicin resistance in Mycobacterium tuberculosis clinical isolates using non-fluorescent low-density DNA microarrays.
The Journal of antimicrobial chemotherapy - 1 May 2006
Aragón Lina Marcela, Navarro Ferran, Heiser Volker, Garrigó Montserrat, Español Montserrat, Coll Pere
Abstract excerpt
BACKGROUND: A new, fast 'low cost and density' DNA microarray (LCD array), designed for the detection of mutations that confer isoniazid or rifampicin resistance in Mycobacterium tuberculosis isolates, has been developed and was evaluated using 46 resistant clinical isolates from Barcelona. METHODS: LCD chips are pre-structured polymer supports using a non-fluorescent detection principle based on the...
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