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Article

The cysteine desulfurase IscS is required for synthesis of all five thiolated nucleosides present in tRNA from Salmonella enterica serovar typhimurium.

Journal of bacteriology - 1 Dec 2002

Nilsson Kristina, Lundgren Hans K, Hagervall Tord G, Björk Glenn R

Abstract excerpt

Deficiency of a modified nucleoside in tRNA often mediates suppression of +1 frameshift mutations. In Salmonella enterica serovar Typhimurium strain TR970 (hisC3737), which requires histidine for growth, a potential +1 frameshifting site, CCC-CAA-UAA, exists within the frameshifting window created by insertion of a C in the hisC gene. This site may be suppressed by peptidyl-tRNAProcmo5UGG (cmo(5)U is...

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Identifiers

PMID: 12446633
DOI: 10.1128/JB.184.24.6830-6835.2002
PMCID: PMC135462

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