Article
Protein engineering of formate dehydrogenase.
Biomolecular engineering - 1 Jun 2006
Tishkov Vladimir I, Popov Vladimir O
Abstract excerpt
NAD+-dependent formate dehydrogenase (FDH, EC 1.2.1.2) is one of the best enzymes for the purpose of NADH regeneration in dehydrogenase-based synthesis of optically active compounds. Low operational stability and high production cost of native FDHs limit their application in commercial production of chiral compounds. The review summarizes the results on engineering of bacterial and yeast FDHs aimed at improving...
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