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Article

Evolution of Glucose Dehydrogenase for Cofactor Regeneration in Bioredox Processes with Denaturing Agents.

Chembiochem : a European journal of chemical biology - 14 Sept 2020

Qian Wen-Zhuo, Ou Ling, Li Chun-Xiu, Pan Jiang, Xu Jian-He, Chen Qi, Zheng Gao-Wei

Abstract excerpt

Glucose dehydrogenase (GDH) is a general tool for driving nicotinamide (NAD(P)H) regeneration in synthetic biochemistry. An increasing number of synthetic bioreactions are carried out in media containing high amounts of organic cosolvents or hydrophobic substrates/products, which often denature native enzymes, including those for cofactor regeneration. In this work, we attempted to improve the chemical stability...

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PMID: 32324965
DOI: 10.1002/cbic.202000196

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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