Article
Anti-interferon-α neutralizing antibody induced telaprevir resistance under the interferon-α plus telaprevir treatment in vitro.
Biochemical and biophysical research communications - 21 Nov 2014
Kuga Chisa, Enomoto Hirayuki, Aizawa Nobuhiro, Takashima Tomoyuki, Ikeda Naoto, Ishii Akio, Sakai Yoshiyuki, Iwata Yoshinori, Tanaka Hironori, Saito Masaki, Iijma Hiroko, Nishiguchi Shuhei
Abstract excerpt
Although the development of anti-interferon (IFN)-α neutralizing antibodies (NAbs) is likely to be a common clinical problem for patients with various diseases treated with IFN, anti-IFN-α NAb has been exceptionally considered to have no clinical significance in the treatment of chronic hepatitis C with pegylated IFN-α (Peg-IFN-α). However, we recently clarified that the presence of NAb was associated with a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.