Role of urease in megasome formation and Helicobacter pylori survival in macrophages.

doi:10.1189/jlb.0106030

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Article

Role of urease in megasome formation and Helicobacter pylori survival in macrophages.

Journal of leukocyte biology - 1 Jun 2006

Schwartz Justin T, Allen Lee-Ann H

Abstract excerpt

Previous studies have demonstrated that Helicobacter pylori (Hp) delays its entry into macrophages and persists inside megasomes, which are poorly acidified and accumulate early endosome autoantigen 1. Herein, we explored the role of Hp urease in bacterial survival in murine peritoneal macrophages and J774 cells. Plasmid-free mutagenesis was used to replace ureA and ureB with chloramphenicol acetyltransferase in...

Topics

Adsorption
Ammonia
Ammonium Chloride
Animals
Autoantigens
Cell Line
Chloroquine
Enzyme Induction
Female
Gene Deletion
Genes, Reporter
Helicobacter pylori

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hydrogen-Ion Concentration

Lysosomal Membrane Proteins

Macrolides

Macrophages

Macrophages, Peritoneal

Membrane Fusion

Source

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Identifiers

PMID: 16543403
DOI: 10.1189/jlb.0106030
PMCID: PMC1868427

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