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Article

Cutting edge: urease release by Helicobacter pylori stimulates macrophage inducible nitric oxide synthase.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2002

Gobert Alain P, Mersey Benjamin D, Cheng Yulan, Blumberg Darren R, Newton Jamie C, Wilson Keith T

Abstract excerpt

Inducible NO synthase (iNOS) expression and production of NO are both up-regulated with Helicobacter pylori infection in vivo and in vitro. We determined whether major pathogenicity proteins released by H. pylori activate iNOS by coculturing macrophages with wild-type or mutant strains deficient in VacA, CagA, picB product, or urease (ureA(-)). When filters were used to separate H. pylori from macrophages, there...

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Share to Antigens, Bacterial
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Nitric Oxide Synthase Type II

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Source

Identifiers

PMID: 12055207
DOI: 10.4049/jimmunol.168.12.6002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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