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Article

CAFE: a computational tool for the study of gene family evolution.

Bioinformatics (Oxford, England) - 15 May 2006

De Bie Tijl, Cristianini Nello, Demuth Jeffery P, Hahn Matthew W

Abstract excerpt

SUMMARY: We present CAFE (Computational Analysis of gene Family Evolution), a tool for the statistical analysis of the evolution of the size of gene families. It uses a stochastic birth and death process to model the evolution of gene family sizes over a phylogeny. For a specified phylogenetic tree, and given the gene family sizes in the extant species, CAFE can estimate the global birth and death rate of gene...

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PMID: 16543274
DOI: 10.1093/bioinformatics/btl097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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