Article
A role for CD4+CD25+ T cells in regulation of the immune response during human tuberculosis.
Clinical and experimental immunology - 1 Apr 2006
Ribeiro-Rodrigues R, Resende Co T, Rojas R, Toossi Z, Dietze R, Boom W H, Maciel E, Hirsch C S
Abstract excerpt
Active tuberculosis (TB) is associated with prolonged suppression of Mycobacterium tuberculosis (MTB)-specific immune responses, but mechanisms involved are understood incompletely. We investigated a potential role for CD4+CD25+ regulatory T cells in depressed anti-MTB immunity by evaluating serially CD4 cell phenotype and interferon (IFN)-gamma production by mononuclear cells from patients with TB. At diagnosis,...
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