Article
Early invasiveness characterizes metastatic carcinoid tumors in transgenic mice.
Cancer research - 15 Sept 1991
Grant S G, Seidman I, Hanahan D, Bautch V L
Abstract excerpt
The conversion of a normal cell into a metastatic tumor is thought to occur in a stepwise progression of genetic changes that affect both growth control and interactions with the extracellular environment. The development of invasiveness allows tumor cells to escape from their primary site. We have investigated transgenic mice that develop both invasive intestinal neuroendocrine tumors and noninvasive tumors of...
Topics
- Animals
- Antigens, Viral, Tumor
- Carcinoid Tumor
- Gene Expression
- Intestinal Neoplasms
- Mice
- Mice, Transgenic
- Neoplasm Invasiveness
- Neoplasm Metastasis
- Pancreatic Neoplasms
- Phenotype