Article
Targeted Expression of Human <b> <i>MYCN</i> </b> Selectively Causes Pancreatic Neuroendocrine Tumors in Transgenic Zebrafish
15 Oct 2004
Abstract excerpt
The zebrafish model organism has been used extensively for studies of genetic pathways in development, indicating its potential applicability to cancer. Here we show that targeted expression of MYCN in cells of the pancreatic islet induces neuroendocrine carcinoma. Four transgenic fish developed abdominal tumors between 4 and 6 months of age, and histologic analysis revealed lobulated arrangements of neoplastic...