Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes.

doi:10.1038/315115a0

Back to search

Article

Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes.

Nature - 1 Jan 2000

Hanahan D

Abstract excerpt

Following the transfer into fertilized mouse eggs of recombinant genes composed of the upstream region of the rat insulin II gene linked to sequences coding for the large-T antigen of simian virus 40, large-T antigen is detected exclusively in the beta-cells of the endocrine pancreas of transgeni...

Topics

Adenoma, Islet Cell
Animals
Antigens, Polyomavirus Transforming
Antigens, Viral, Tumor
Cell Communication
DNA, Recombinant
Gene Expression Regulation
Insulin
Mice
Oncogenes
Pancreatic Neoplasms
Pedigree
Phenotype
Simian virus 40
Tissue Distribution
Viral Proteins

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.